Virus Filtration
Virus removal filtration is regarded as a very effective and robust step for virus retention and has been widely applied in biologics manufacturing due to advantages such as simple and gentle operation, clear mechanism and ease of validation.
Virus removal filters with a cut-off pore size of 20 nm are the most widely used solution as it provides high retention assurance toward minute viruses.
Viruclear® PVF – Disposable Capsule Filters with PVDF Shell
The Viruclear® PVF virus removal filter adopts a PES membrane with a continuous gradient structure. It provides sufficient space for retention of the foulant which are basically protein aggregates. The pore size on the downstream side of the membrane is uniformly distributed around 20 nm that endows the membrane with robust virus retention even under the condition of process interruption or depressurisation. This virus filters are available with filtration areas from 0.017 m² to 1.5 m².
Features:
- PES membrane has a unique surface hydrophilic improvement, which endows virus removal membranes with high filtration capacity and high recovers
- Asymmetric membrane structure, high porosity, which endows the membrane with high flux
- Water flux greater than 600 LMH at 2.0 bar (30 psi) and 25 °C
- Narrow pore size distribution gives the membrane good separation performance
- Robust parvovirus removal capacity
- Mode virus removal rate ≥ 4.0 log
- Maintain robust virus removal capacity even under process interruption
- Good chemical stability
- Easy to install, use and test
Applications:
- Monoclonal antibody
- Bispecific monoclonal antibody
- Fc-fusion protein
- Nanobody
- Recombinant Covid-19 vaccine
- Small molecule recombinant proteins (< 180 kD), etc.
Viruclear® VF – Membrane Cassettes with Silicone Shell
The Viruclear® VF virus removal membrane cassette adopts a hydrophilic modified PES membrane. The upgradation gives improved mass capacity and adaptability across a broad range of typical protein feed streams, thus brings increased process economics. The Viruclear® VF also enables robust linear scale-up and easy process optimisation. This virus filters are available with filtration areas from 0.018 m² to 1.5 m².
Features:
- PES membrane has a unique surface hydrophilic improvement, which endows virus removal membranes with high filtration capacity and high recovers
- Asymmetric membrane structure, high porosity, which endows the membrane with high flux
- Water flux greater than 600 LMH at 2.0 bar (30 psi) and 25°C
- Narrow pore size distribution gives the membrane good separation performance
- Robust parvovirus removal capacity
- Mode virus removal rate ≥ 4.0 log
- Maintain robust virus removal capacity even under process interruption
- Good chemical stability
- Easy to install, use and test
Applications:
- Monoclonal antibody
- Bispecific monoclonal antibody
- Fc-fusion protein
- Nanobody
- Recombinant Covid-19 vaccine
- Small molecule recombinant proteins (< 180 kD), etc.